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EDUCATION AND RESEARCH EXPERIENCE
| 1994-1998 |
Bachelor, University of Science and Technology of China, China |
| 1998-2003 |
Ph. D, University of Science and Technology of China, China |
| 2003-2007 |
Post-doctoral fellow, National Jewish Medical and Research Center, UCHSC, USA |
| 2007- Present |
Professor, University of Science and Technology of China, China |
RESEARCH INTERESTS
| 1) |
Structural basis of epigenetic inheritance |
| 2) |
Structural basis of immune escape of pathogens |
CURRENT RESEARCH PROJECTS
| 1) |
Structural basis for protein modification, Ministry of Science & Technology of China |
| 2) |
Study the structural and functional roles of RNA degradosome of Staphylococcus aureus, National Natural Science Foundation of China |
| 3) |
Structural biological research of histone demethylases toward H3K36, National Natural Science Foundation of China |
REPRESENTATIVE PUBLICATIONS
| 1) |
Wang, H., Zhou, X., Wu, M., Wang, C., Zhang, X., Tao, Y., Chen, N. and Zang, J. (2013) Structure of the JmjC-domain-containing protein JMJD5. Acta Crystallogr D Biol Crystallogr, 69, 1911-1920. |
| 2) |
Tao, Y., Wu, M., Zhou, X., Yin, W., Hu, B., de Crombrugghe, B., Sinha, K.M. and Zang, J. (2013) Structural Insights into Histone Demethylase NO66 in Interaction with Osteoblast-specific Transcription Factor Osterix and Gene Repression. J Biol Chem, 288, 16430-16437. |
| 3) |
Wu, M., Tao, Y., Liu, X. and Zang, J. (2013) Structural Basis for Phosphorylated Autoinducer-2 Modulation of the Oligomerization State of the Global Transcription Regulator LsrR from Escherichia coli. J Biol Chem, 288, 15878-15887. |
| 4) |
Zhang, X., Chen, J., Wu, M., Wu, H., Arokiaraj, A.W., Wang, C., Zhang, W., Tao, Y., Huen, M.S. and Zang, J. (2013) Structural basis for role of ring finger protein RNF168 RING domain. Cell Cycle, 12, 312-321. |
| 5) |
Ruan, J., Xu, C., Bian, C., Lam, R., Wang, J.P., Kania, J., Min, J. and Zang, J. (2012) Crystal structures of the coil 2B fragment and the globular tail domain of human lamin B1. FEBS Lett, 586, 314-318. |
| 6) |
Li, J., Wang, C., Wu, Y., Wu, M., Wang, L., Wang, Y. and Zang, J. (2012) Crystal structure of Sa239 reveals the structural basis for the activation of ribokinase by monovalent cations. J Struct Biol, 177, 578-582. |
| 7) |
Bian, C., Xu, C., Ruan, J., Lee, K. K., Burke, T. L., Tempel, W., Barsyte, D., Li, J., Wu, M., Zhou, B. O., Fleharty, B. E., Paulson, A., Allali-Hassani, A., Zhou, J. Q., Mer, G., Grant, P. A., Workman, J. L.*, Zang, J.* & Min, J.* (2011). Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. EMBO J 30, 2829-42. (*Co-corresponding author) |
| 8) |
Wang, L., Wu, M. & Zang, J. (2011). Crystal structure of Sa240: A ribose pyranase homolog with partial active site from Staphylococcus aureus. J Struct Biol 174, 413-9. |
| 9) |
Hong, X.*, Zang, J.*, White, J.*, Wang, C., Pan, C. H., Zhao, R., Murphy, R. C., Dai, S., Henson, P., Kappler, J. W., Hagman, J. & Zhang, G. (2010). Interaction of JMJD6 with single-stranded RNA. Proc Natl Acad Sci USA 107, 14568-72. (*Co-first author) |
| 10) |
Liu, Y., Huang, H., Zhou, B. O., Wang, S. S., Hu, Y., Li, X., Liu, J., Zang, J., Niu, L., Wu, J., Zhou, J. Q., Teng, M. & Shi, Y. (2010). Structural analysis of Rtt106p reveals a DNA binding role required for heterochromatin silencing. J Biol Chem 285, 4251-62. |
| 11) |
Lai, C., Wu, M., Li, P., Shi, C., Tian, C. & Zang, J. (2010). Solution NMR characterization of Sgf73(1-104) indicates that Zn ion is required to stabilize zinc finger motif. Biochem Biophys Res Commun 397, 436-40. |
| 12) |
Wang, J., Zhang, W., Song, W., Wang, Y., Yu, Z., Li, J., Wu, M., Wang, L., Zang, J. & Lin, Q. (2010). A biosynthetic route to photoclick chemistry on proteins. J Am Chem Soc 132, 14812-8. |
| 13) |
Zhu, Z., Gao, Y., Yu, Y., Zhang, X., Zang, J., Teng, M. & Niu, L. (2009). Structural basis of the autolysis of AaHIV suggests a novel target recognizing model for ADAM/reprolysin family proteins. Biochem Biophys Res Commun 386, 159-64. |
| 14) |
Chen, Z., Zang, J., Kappler, J., Hong, X., Crawford, F., Wang, Q., Lan, F., Jiang, C., Whetstine, J., Dai, S., Hansen, K., Shi, Y. & Zhang, G. (2007). Structural basis of the recognition of a methylated histone tail by JMJD2A. Proc Natl Acad Sci USA 104, 10818-23. |
| 15) |
Chen, Z.*, Zang, J.*, Whetstine, J., Hong, X., Davrazou, F., Kutateladze, T. G., Simpson, M., Mao, Q., Pan, C. H., Dai, S., Hagman, J., Hansen, K., Shi, Y. & Zhang, G. (2006). Structural insights into histone demethylation by JMJD2 family members. Cell 125, 691-702. (*Co-first author) |
| 16) |
Wang, D., Guo, M., Liang, Z., Fan, J., Zhu, Z., Zang, J., Li, X., Teng, M., Niu, L., Dong, Y. & Liu, P. (2005). Crystal structure of human vacuolar protein sorting protein 29 reveals a phosphodiesterase/nuclease-like fold and two protein-protein interaction sites. J Biol Chem 280, 22962-7. |
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